Healing of experimental femoral defects in rats after implantation of collagen-calcium phosphate biocomposites

Healing of experimental femoral defects in rats after implantation of collagen-calcium phosphate biocomposites

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The aim of this study was to investigate the healing process of experimental defects of the femoral shaft diaphysis of rats after implantation of osteoplastic material Food Storage Collapan into its cavity.In experi-mental animals, a perforated defect with diameter of 2.5 mm was created in the medullary canal of the femoral shaft and filled with osteoplastic material Collapan.In control rats, the defect was left un-filled.The bone fragments were examined on the 15th and 30th day by light microscopy morphometry and scanning electron microscopy.

It was found that application of osteoplastic material Collapan in the femoral diaphysis defect Dryer Vent Extension optimised reparative osteogenesis, showed high biocompatibility, osteo-conductive properties, resorption ability and good integration with tissue-specific structures of the regenerate.